+963 11 4474477
info@avicenna-labs.co
Damascus - Syria

Human Medicines

Home Pain relievers and fever reducers
SINADOL TABLETS

SINADOL TABLETS

Therapeutic Category
Pain relievers and fever reducers
Pharmaceutical Form
Tablets
Chemical Name
Paracetamol

Leaflet

Chemical Composition

Each tablet contains:

  • Paracetamol 500 mg
Indications
  • Relief of mild to moderate pain (headache, toothache, muscle pain, back pain, menstrual pain).
  • Reduces fever in cases of high temperature.

  • Relieves pain associated with colds and influenza.
    • Dosage and Method of Administration
  • Adults and adolescents (≥12 years): 500–1000 mg (1–2 tablets) every 4–6 hours as needed, not exceeding 4 g/day.
  • Children (6–12 years): 250–500 mg every 4–6 hours as needed (maximum dose 2 g/day).
  • Children under 6 years: It is preferable to use appropriate dosage forms (suspensions or suppositories).

  • Do not exceed the prescribed dose and do not use for more than 3 days as a fever reducer or 5 days as a pain reliever without consulting a doctor.
    • Contraindications
  • Hypersensitivity to paracetamol or any of the components of the product.

  • Severe liver disease or acute hepatic failure.
    • Usage Warnings
  • Caution should be taken in patients with liver diseases or chronic alcohol use.
  • Caution is required when used with other medications containing paracetamol (risk of exceeding the toxic dose).
  • It is not recommended to exceed the maximum daily dose to avoid liver toxicity.

  • Long-term use may require monitoring of liver and kidney functions.
    • DRUG INTERACTIONS
    1. Alcohol: Increases the risk of liver toxicity.
    2. Rifampicin, Carbamazepine, Phenytoin, Barbiturates: May increase the hepatic toxicity of paracetamol by accelerating its metabolism.
    3. Warfarin and oral anticoagulants: Chronic use may increase the risk of bleeding.
    4. Chloramphenicol: May prolong its half-life when used together.
    Side Effects
  • Rare when used at recommended doses.
  • May include: nausea, vomiting, stomach pain, headache.
  • Rare allergic skin reactions (rash, itching, angioedema).
  • Severe liver toxicity when exceeding the recommended dose.
    • Pregnancy and Breastfeeding
  • Pregnancy: Considered relatively safe when used at recommended doses, and is a preferred pain reliever and fever reducer during pregnancy.

  • Breastfeeding: Excreted in small amounts in breast milk and considered safe at therapeutic doses.
    • Pregnancy classification
    • FDA Classification: Category B (no proven risk to the fetus when used correctly). 
    Overdose
    • May cause: nausea, vomiting, sweating, pallor, abdominal pain, followed by liver damage (which may progress to acute liver failure).
    • Toxic dose: usually >10 g in adults or >150 mg/kg in children.
    • Treatment:
      • Immediate transfer to hospital.
      • Administration of the antidote (N-acetylcysteine) as soon as possible.
      • Supportive care with monitoring of liver function. 
    Conditions for Preservation
  • Store at a temperature below 25°C.
  • Keep away from moisture, heat, and direct light.

  • Keep out of reach of children.